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KMID : 0371320080740040312
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Journal of the Korean Surgical Society
2008 Volume.74 No. 4 p.312 ~ p.315
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Mesenteric Fibromatosis Presenting as a Submucosal Tumor of the Jejunum
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Yoo Chang-Young
Jung Chan-Kwon
Song Kyo-Young
Jung Eun-Sun
Lee Kyo-Young
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Abstract
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Mesenteric fibromatoses occur as sporadic lesions or as parts of familial adenomatous polyposis, are clonal lesions prone to locally aggressive behavior, but lack metastatic capacity. Fibromatoses harbor somatic ?-catenin or adenomatous polyposis coli (APC) mutations, leading to intranuclear accumulation of b-catenin. We report a case of mesenteric fibromatosis presenting as a 5.4x4.8 cm submucosal tumor of the jejunum in a 42-year-old woman. Histologically, the tumor consisted of proliferation of bland, elongated-spindle fibroblasts with collagen deposition and a characteristic prominent vasculature. Immunohistochemically, the tumor cells showed nuclear staining for ?-catenin. Mesenteric fibromatosis should be included in the differential diagnosis of submucosal spindle cell tumors of the gastrointestinal tract, and nuclear immunoreactivity for ?-catenin may help distinguish these tumors form histological mimics. (J Korean Surg Soc 2008;74:312-315)
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KEYWORD
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Mesenteric fibromatosis, ?-catenin, Immunohistochemistry, Small intestine
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